Drug delivery to the human eye is a rapidly growing area in the pharmaceutical industry, but it is also one of the most challenging. The inherent structure and physiology of the eye make it difficult for drugs to reach the site of action and persist over time. Despite these constraints, ocular therapies continue to garner significant interest due to the growing patient need. 

Despite the recent growth in ocular injectable products, topicals remain the most prominent dosage form for ophthalmic products and those in development. This trend has resulted in an all-encompassing surge in the development of treatments for eye disease. However, all ophthalmic products face challenges. 

The administration of the anterior part of the eye mainly affects the anterior part of the eye, usually penetrating the cornea to achieve the purpose of administration. Cornea is a transparent layer covering the visible part of the eye, used to focus light. For example, eye drops and other external liquid preparations are transported by cornea.

Some of the main hindrances in topical ocular delivery result from the inherent nature of standard topicals, as well as the natural mechanisms of the eye. The average eye drop is 30-50 μL, whereas the tear film capacity of the eye is only 6-8 μL, resulting in a large waste of product and presenting a significant delivery limitation. 

Th key property is mucosal adhesion or bio adhesiveness for ophthalmic products.

The general definition of bio adhesiveness is the adhesion between two surfaces, at least one of which is biological surface. For external ophthalmic drugs, one surface is the surface formed by liquid drugs, the other is the surface of the front of the eye. We can achieve bio adhesiveness in the formulation with a series of different components and drug delivery systems. The optional polymers are the NM-Carbomer series.

We, Anhui Newman Fine chemicals. Co., ltd is the top leading manufacturer of carbomer/Carbopol products, we have both cosmetics grade and pharmaceuticals grade carbomer. NM-934P, Carbopol 980NF/Carbomer 970G, Carbopol 981NF/Carbomer 981G as excipient in pharmaceutical fields, meet pharmacopeia monograph. They have been successfully used in ophthalmic products and pharmaceutical formulations to impart rheology modification, cohesion, controlled drug release, and many other unique properties., including,

1)Ideal Aesthetic and Sensory Qualities – increase patient compliance through low-irritation, aesthetically pleasing formulations with optimal feel

2)Bioadhesion / Mucoadhesion – optimize drug delivery by prolonging product contact with biological membranes, improve patient compliance via reduced need for frequent drug administration, and protect and lubricate mucosal surfaces

3)Efficient Rheology Modification and thickening for topical semisolids.